14 Feb [MCE] Natural Antiviral Products
From the early smallpox virus to SARS-CoV-2, every pandemic of viral infections poses a severe threat to human health[1][2]. Due to the virus’s mutability, infectivity, and drug resistance, vaccines and antiviral drugs targeting the virus need to be continuously improved[3]. So far, many viral diseases still lack effective therapeutic drugs, and natural products with diverse chemical structures and extensive pharmacological activities, making them essential source for discovery of new antiviral drugs[4].
Natural Product Antiviral Advantages
Natural products have more diverse ways of acting than synthetic compounds acting on a specific target during viral infection. Taking anti-SARS CoV-2 as an example, in addition to targeting some key proteins (3CLpro, ACE2, FURIN and RdRp), natural products also have immunomodulatory, anti-inflammatory and anti liver failure activities, which can regulate immune balance and reduce infection symptoms during the treatment of COVID-19[5].
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Application of Natural Antiviral Products
Many classic natural products have antiviral activity. For example, stilbene compounds (molecules with a styrene backbone and their polymers) represented by Resveratrol have extensive antiviral activity. Stilbene compounds can exist as monomers or polymers with a vast amount, providing a material basis for discovering new antiviral drugs[6].
MCE Provides a Variety of Natural Antiviral Products
| Structural Classification |
Product Name | Function |
|---|---|---|
| Stilbene | Resveratrol | Specific SIRT1 activator, PXR inhibitor, Nrf2 activator; Other targets: mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase; Anti-viral, anti-cancer, anti-inflammatory, antioxidant, cardioprotective activities. |
| Pterostilbene | SARS-COV-2 replication inhibitor; Suppress ROS generation; Anti-viral, anti-cancer, antioxidant, anti-inflammatory, and anti-diabetic effects. |
|
| Piceatannol | Syk inhibitor; Induces apoptosis and autophagy; Anti-cancer, anti-inflammatory, and anti-viral activities. |
|
| Oxyresveratrol | Non-competitive tyrosinase inhibitor, antioxidant, free radical scavenger; Antiviral effcts, such as HSV-1, HSV-2, and varicella-zoster virus. |
|
| Alkaloid | Cepharanthine | SARS-CoV-2 inhibitor, Cytochrome P450 inhibitor; Antiviral, anticancer, anti-inflammatory, and analgesic effects. |
| Flavone | Glabrone | Specific UGT1A9 probe substrate; Inhibits influenza virus. |
| Benzene Quinones |
Geldanamycin | Hsp90 inhibitor, H5N1 inhibitor; Antiviral and anticancer activities. |
| Lignan | Clemastanin B | Viral proliferation inhibitor; Targets viral endocytosis, uncoating, or ribonucleoprotein (RNP) export from the nucleus. |
References: |
| [1] Biomed Res Int. 2021 Dec 8; 2021:7872406. [2] Eur J Med Chem. 2020 Dec 1; 207: 112790. [3] Environ Sci Pollut Res Int. 2022 Jun; 29(28): 42404-42432. [4] Eur J Med Chem. 2023 Nov 15; 260: 115726. [5] Phytother Res. 2022 Oct; 36(10): 3833-3858. |
