07 Aug [MCE] New Products July 2023
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
• Over 50,000 bioactive molecules in stock
• Target 1,000+ key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 1,000 latest biochemicals per month
• Data sheet with detailed biological information
• High purity & competitive prices
• Delivery within 24 hours
Pyridinium bisretinoid A2E TFA
Research Area: Apoptosis/Autophagy/ROS
- An initiator of blue-light-induced apoptosis.
- Mediates autophagy and the production of reactive oxygen species.
- The first fluorophore isolated from RPE lipofuscin, damages RPE cells and used in the study for retinal degenerative diseases
Solubility: DMSO : 100 mg/mL (141.66 mM; Need ultrasonic)
CAS No.: 2102347-47-5
LFHP-1c
Research Area: Phospholipase/Cardiovascular Disease
- An initiator of blue-light-induced apoptosis.
- Mediates autophagy and the production of reactive oxygen species.
- The first fluorophore isolated from RPE lipofuscin, damages RPE cells and used in the study for retinal degenerative diseases.
Solubility: DMSO : 100 mg/mL (141.66 mM; Need ultrasonic)
CAS No.: 2259884-03-0
Mazdutide
Research Area: GLP Receptor/Diabetes
- A long-acting synthetic oxyntomodulin analog.
- A glucagon-like peptide-1 (GLP-1R)/glucagon receptor GCGR co-agonist.
- Used for the research in obesity and type 2 diabetes (T2D).
Solubility: H2O : 22.22 mg/mL (ultrasonic and adjust pH to 2 with HCl)
CAS No.: 875258-85-8
YIL781
Research Area: GHSR/Metabolic Disease
- A potent and orally active ghrelin receptor (GHSR) antagonist.
- Produces a greater improvement in glucose homeostasis in rats.
- Inhibits the calcium response induced by ghrelin.
Solubility: DMSO : 100 mg/mL (244.20 mM; Need ultrasonic)
CAS No.: 16705-03-6
Demethyleneberberine chloride
Research Area: NF-κB/AMPK/Metabolic Disease/Inflammation/Immunology
- A natural mitochondria-targeted antioxidant.
- Alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway.
- An AMPK activator for non-alcoholic fatty liver disease (NAFLD) study.
Solubility: DMSO : 2 mg/mL (5.56 mM; Need ultrasonic)
MCE New Compound Library in May
A membrane protein is a protein molecule that is attached to or associated with the membrane of a cell or an organelle. Membrane proteins can be classified into two groups based on how the protein is associated with the membrane: integral membrane proteins and peripheral membrane proteins. In humans, about 30% genome encodes membrane proteins. Membrane proteins perform a variety of functions vital to the survival of organisms, for example, signal transduction, molecules or ion transportation, enzymatic catalysis, and intercellular communication. Membrane proteins also play important roles in drug discovery. As reported, more than 60% of current drug targets are membrane proteins.
MCE supplies a unique collection of 6,000+ compounds targeting a variety of membrane proteins and 4,000+ compounds targeting a variety of membrane receptors, which can be used for membrane proteins or membrane receptor-focused screening and drug discovery.
| Compound Library | Compound Number | Description |
Membrane Protein-targeted Compound Library |
6,000+ | Targets such as GLUT, GABA Receptor, VEGFR, GPR88, Adrenergic Receptor, 5-HT Receptor, ion channel, etc. |
Membrane Receptor-targeted Compound Library |
4,000+ | Targets such as FGFR, TRP Channel, VEGFR, TNF Receptor, Opioid Receptor, 5-HT Receptor, ion channel, etc. |
MCE Basement membrane matrix
Basement membrane is extracellular matrix under cells in vivo. MCE basement membrane matrix is a basement membrane preparation from extracellular matrix protein-rich mouse tumors. Its main components include laminin, type IV collagen, heparin acetyl sulfate proteoglycan (HSPG), and nestin, as well as various growth factors such as TGF-β, EGF, IGF, FGF, etc.
MCE basement membrane matrix is guaranteed to be LDEV-free, with complete functional validation data and high batch-to-batch consistency, which is suitable for in vitro 3D cell culture, organoid construction, and tumor cell invasion experiments.
| Product Name | Application |
Basement Membrane Matrix (Phenol Red) |
Cell culture, e.g., epithelial cells; promotes differentiation of multiple cell types, e.g., neurons, hepatocytes. |
Basement Membrane Matrix |
Cell culture, e.g., epithelial cells; promotes differentiation of multiple cell types, e.g., neurons, hepatocytes. No effect on subsequent color identification experiments. |
Basement Membrane Matrix GFR (Phenol Red) |
Need to reduce growth factor-induced cell culture, such as osteoblast signaling optimization. |
Basement Membrane Matrix GFR |
Need to reduce growth factor-induced cell culture, such as osteoblast signaling optimization. No effect on subsequent color identification experiments. |
Basement Membrane Matrix HC (Phenol Red) |
Angiogenesis experiments, animal models and 3D tumor model construction. |
Basement Membrane Matrix IPSC-qualified |
Stem cell culture. |
Basement Membrane Matrix for Organoid Culture |
Organoid construction. |
Latest Publications Citing Use of MCE Products
Nature.
2023 Jun;618(7966):799-807.
Nature.
2023 Jun;618(7966):862-870.
Cell.
2023 Jun 22;186(13):2929-2949.e20.
Cell.
2023 Jun 8;186(12):2628-2643.e21.
