17 Oct [MCE] New products for September 2023
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
| • Over 50,000 bioactive molecules in stock | |
| • Target 1,000+ key proteins in 20+ signaling pathways | |
| • Quality reports (LC/MS, NMR and HPLC) for each product | |
| • Release more than 1,000 latest biochemicals per month | |
| • Data sheet with detailed biological information | |
| • High purity & competitive prices | |
| • Delivery within 24 hours | |
|
CAS No.: 2937327-93-8 |
|||||||||
|
|||||||||
|
|||||||||
|
Solubility: DMSO : 250 mg/mL (536.98 mM; Need ultrasonic) |
|||||||||
|
CAS No.: 2089314-64-5 |
|||||||||
|
|||||||||
|
|||||||||
|
Solubility: DMSO : 125 mg/mL (293.11 mM; Need ultrasonic) |
|||||||||
|
CAS No.: 2924573-90-8 |
|||||||||||
|
|||||||||||
|
|||||||||||
|
Solubility: DMSO : 100 mg/mL (277.52 mM; Need ultrasonic) |
|||||||||||
|
CAS No.: 1507370-40-2 |
|||||||||||
|
|||||||||||
|
|||||||||||
|
Solubility: DMSO : 125 mg/mL (307.45 mM; Need ultrasonic) |
|||||||||||
| MCE New Compound Library in August | ||
|
|
||
| HY-L156 Autoimmune Disease Compound Library Autoimmune disease is a pathological disease characterized by imbalance of inflammatory cytokines. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF, IL-1 β, IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL). MCE designs a unique collection of 400+ autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs. |
||
| HY-L161 Cytokine Inhibitors Library Cytokines are a kind of low molecular soluble proteins synthesized and secreted by cells which induced by immunogen, mitogen or other factors. Cytokines have functions of regulating innate and adaptive immune responses, promoting hematopoiesis, stimulating cell activation, proliferation and differentiation. The imbalance of inflammatory cytokines is one of the important reasons for the occurrence of autoimmune diseases. Cytokine inhibitors are a class of essential compounds that act by directly inhibiting the synthesis and release of cytokine or blocking the binding of cytokine to their receptors. MCE designs a unique collection of 900+ cytokine inhibitors, mainly targeting the IL, CSF, IFN, TNF, GF, etc., which is an effective tool for development and research of anti-autoimmune diseases, anti-cancer and anti-chronic inflammatory diseases compounds. |
||
| Endogenous metabolites | |||||||||||||||||||
|
|
|||||||||||||||||||
| Endogenous metabolites are compounds produced by the body during metabolism, excluding substances derived from the metabolism of exogenous foods or drugs. In addition to maintaining basic life activities, endogenous metabolites also have important pharmacological effects. 1) A target for disease treatment, for example, Cholesterol as a target for hypercholesterolemia treatment. 2) A biomarker to diagnose or detect specific diseases and their therapeutic effects, such as blood sugar levels for diabetes. 3) As an important source of new drug development, such as hormone drugs. |
|||||||||||||||||||
|
|||||||||||||||||||
| MCE Glycoscience Tools Enzymes | |||||||||||||||||||
|
|
|||||||||||||||||||
| Glycosylation is the process of attaching sugars to proteins under the action of glycosyltransferases to form glycosidic bonds with amino acid residues on proteins, which is the most abundant and diverse form of post-translational modification of proteins that is common to all eukaryotic cells. Glycosylation regulates the function and activity of proteins and affects biological processes such as cell recognition, differentiation, signal transduction, and immune response, etc. MCE offers a wide variety of enzymes for the glycosciences, click here for an up-to-date list of MCE enzymes! | |||||||||||||||||||
|
|||||||||||||||||||
| MCE Isotope-labeled Compounds | ||||||||||||||||
|
|
||||||||||||||||
|
||||||||||||||||
| Latest Publications Citing Use of MCE Products | |||
 |
Nature. 2023 Aug;620(7973):426-433. |
||
| Cancer Cell. 2023 Jun 12;41(6):1170-1185.e12. |
|||
| Signal Transduct Target Ther. 2023 Jul 17;8(1):273. |
|||
| Immunity. 2023 Jun 13;56(6):1303-1319.e5. |
|||
