20 Sep [MCE]: New Bioactive Molecules for September 2022
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
• Over 40,000 bioactive molecules in stock
• Target 500+ key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 1,000+ newest biochemicals per month
• Data sheet with detailed biological information
• High purity & competitive prices
CAS No.: 2256084-03-2
Sugemalimab
Research Area: Anti-PD-L1 Antibody/Non-small Cell Lung Cancer (NSCLC)
• A fully human, full length, anti-PD-L1 IgG4 monoclonal antibody (mAb).
• Used for the research of NSCLC, advanced solid tumours and lymphoma.
Solution: 30 mg/mL
CAS No.: 1818864-51-5
MC-VA-PABC-MMAE
Research Area: Drug-Linker Conjugates for ADC
• Consists a cleavable ADC linker (MC-VA-PABC) and a tubulin polymerization inhibitor MMAE.
• Inhibits cell division and anticancer activity.
• Used for the synthesis of antibody-drug conjugates (ADCs).
DMSO: 100 mg/mL (81.27 mM; Need ultrasonic)
CAS No.: 2055200-88-7
BMS-986224
Research Area: APJ Receptor Agonist/Heart Failure
• A potent, selective and orally active APJ receptor agonist with a Kd value of 0.3 nM.
• Has the potential for heart failure research.
DMSO: 20.83 mg/mL (ultrasonic; warming; heat to 60°C)
CAS No.: 2756333-39-6
AZD-9574
Research Area: PARP1 Inhibitor/Brain Malignancies
• A selective and CNS penetrant PARP1 inhibitor that acts by inhibiting and trapping PARP1 at the sites of DNA single-strand breaks (SSBs).
• Used for primary and secondary brain malignancies research.
DMSO: 22.22 mg/mL (51.86 mM; ultrasonic and adjust pH to 4 with HCl)
CAS No.: 2254004-96-9
DDO-7263
Research Area: Nrf2 Activator/Parkinson’s Disease
• A potent Nrf2 Activator with anti-inflammatory activity.
• Upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2.
• Neuroprotective effect is mediated by Nrf2 activation and NLRP3 inflammasome inhibition.
DMSO: 17.86 mg/mL (ultrasonic; warming; heat to 60°C)
| Compound Library | Description |
| Anti-Prostate Cancer Compound Library |
1,800+ compounds with identified and potential anti-prostate cancer activity;
Containing IGF-1, TGF-α, EGF, Wnt, Hedgehog, NF-κB, and mTOR and other signaling pathways; A useful tool for anti-prostate cancer drugs screening and other related research. |
| Anti-Pulmonary Fibrosis Compound Library | 1,200+ compounds with identified and potential anti-pulmonary fibrosis activity; A useful tool for anti-pulmonary fibrosis drugs screening and other related research. |
| Anti-Orthopoxvirus Compound Library |
30+ compounds reported with the anti-orthopoxvirus activity which can be used for drug screening and other research about orthopoxvirus.
|
Anti-His Magnetic Beads
| Characteristics | ||
| Composition | Composition Mouse IgG monoclonal antibody covalently coupled to a blocked magnetic bead surface | |
| Bead Diameter | 2 μm |
|
| Binding Capacity | > 0.5 mg protein/mL of beads |
|
| Application | IP, Co-IP, Protein Purification |
|
| Recommended Dose | 25 μL for per 500 μL cell lysates |
CEPT Cocktail
Cell. 2022 Aug 18;185(17):3124-3137.e15.
Nature. 2022 Aug;608(7923):609-617.
Immunity. 2022 Aug 9;55(8):1466-1482.e9.
Cell. 2022 Aug 4;185(16):3008-3024.e16.
Cell Signaling Pathways
Request Your Quote