07 Oct [MCE]: New Bioactive Molecules for October 2022
MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 40,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via info@bio-etc.com.
CAS No.: 1515887-44-1
UCB-5307
Research Area: TNF Inhibitor/Inflammation
• A potent TNF Inhibitor, with a Kd value of 9 nM for human TNFα.
• Inhibits wild-type TNF but does not inhibit L57F TNF.
• Has the ability to disrupt a preformed hTNF/hTNFR1 complex.
Solubility: DMSO : 50 mg/mL (145.59 mM; Need ultrasonic)
CAS No.: 2660250-10-0
BLU-945
Research Area: EGFR Inhibitor/Non-Small Cell Lung Cancer (NSCLC)
• A selective and orally active fourth-generation EGFR inhibitor with a robust antitumor activity.
• Potently inhibits EGFR+/T790M and EGFR+/T790M/C797S resistant mutants that maintains activity against the sensitizing mutations, especially L858R.
• Used for the research of the resistant EGFR-driven NSCLC.
Solubility: DMSO : 125 mg/mL (224.54 mM; ultrasonic and warming and heat to 60°C)
CAS No.: 2729996-45-4
GNE-9815
Research Area: RAF Kinase Inhibitor/KRAS Mutant Cancers
• A highly selective and orally active type II pan-RAF inhibitor, with an anticancer effect.
• Shows synergistic activity in KRAS mutant A549 and HCT116 cancer cells in combination with the MEK inhibitor Cobimetinib.
Solubility: DMSO : 50 mg/mL (109.77 mM; ultrasonic and warming and heat to 80°C)
CAS No.: 2411819-82-2
NBD-14270
Research Area: HIV-1 Entry Antagonist/HIV-1 Infection
• A potent HIV-1 gp120 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses.
• Has potent antiviral activity and low cytotoxicity.
Solubility: DMSO : 100 mg/mL (235.06 mM; Need ultrasonic)
CAS No.: 951659-40-8
Flupyradifurone
Research Area: nAChR Agonist/Systemic Insecticide
• A systemic nAChR agonist that interferes with signal transduction in the central nervous system of sucking pests.
• Used as a butenolide insecticide, and shows efficient protection to crops.
Solubility: DMSO : 100 mg/mL (346.40 mM; Need ultrasonic)
| Compound Library | Description |
| Human Metabolite Library |
4,000+ human metabolites, including endogenous metabolites and exogenous metabolites;
Covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins; A helpful tool for studying the relationship between diseases and metabolism. |
| Nuclear Receptor Compound Library | 500+ nuclear receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on nuclear receptor; A useful tool for drugs research related to cancer, skin disease and diabetes. |
Nucleic acid extraction and purification
| Cat. No. | Product | Size | Application |
| HY-K1081 |
Genomic DNA Mini Purification Kit
|
50T | Purification of Genomic DNA |
| HY-K1082 |
Viral DNA/RNA Mini Purification Kit
|
50T | Purification of Viral DNA/ RNA |
| HY-K1083 | Plasmid DNA Maxi Purification Kit | 20T |
Purification of Plasmid DNA
|
Nature. 2022 Sep;609(7928):829-834.
Cell. 2022 Sep 1;185(18):3356-3374.e22.
Cancer Cell. 2022 Sep 12;40(9):1044-1059.e8.
Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9.
Cell Signaling Pathways
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