09 Nov [MCE]: New Bioactive Molecules for November 2022
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
• Over 40,000 bioactive molecules in stock
• Target 500+ key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 1000+ newest biochemicals per month
• Data sheet with detailed biological information
• High purity & competitive prices
CAS No.: 2417987-45-0
GDC-6036
Research Area: KRAS G12C Inhibitor/KRAS G12C Mutant Cancers
• An orally active and selective KRAS G12C inhibitor with anticancer activity.
• Covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.
• Demonstrates complete tumor growth inhibition in multiple KRAS G12C-positive cell lines and in xenograft mouse models.
Solubility: DMSO : 100 mg/mL (160.76 mM; Need ultrasonic)
CAS No.: 756875-51-1
K6PC-5
Research Area: SPHK1 Activator/Skin Disorders
• A selective sphingosine kinase 1 (SPHK1) activator that induces increased calcium levels in keratinocytes.
• Promotes differentiation and proliferation of keratinocytes via intracellular Ca2+ signaling.
• Has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration research.
Solubility: DMSO : 100 mg/mL (291.12 mM; Need ultrasonic)
CAS No.: 76326-31-3
DL-AP5
Research Area: NMDA Receptor Antagonist/Neurological Disease
• A competitive NMDA receptor antagonist acts at the glutamate site.
• A racemic mixture of the D- and L-isomers of AP5, and can be used in the research of synaptic plasticity.
Solubility: H2O : 33.33 mg/mL (169.08 mM; ultrasonic and warming and heat to 60°C)
CAS No.: 1141397-80-9
Cedazuridine
Research Area: Cytidine Deaminase (CDA) Inhibitor/Myelodysplastic Syndrome
• An orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM.
• In combinations with Decitabine for the study of myelodysplastic syndromes (MDS), including chronic myelomonocytic leukemia (CMML), and certain types of anemia.
• A fluorinated Tetrahydrouridine derivative specifically prevents hypomethylating agents breakdown, and increases their bioavailability and efficacy.
Solubility: DMSO : 125 mg/mL (466.05 mM; Need ultrasonic)
CAS No.: 2756818-39-8
SB-216
Research Area: Tubulin Polymerization Inhibitor/Pancreatic, Melanoma, Breast/Lung Cancer
• A potent tubulin polymerization inhibitor with robust anti-tumor activity.
• Targets the Colchicine binding site and serves as a potent anti-cancer agent for various cancer types.
• Demonstrates strong antiproliferative potency, and causes G2/M cell cycle arrest and cell apoptosis in a panel of human cancer cell lines.
Solubility: DMSO : 62.5 mg/mL (201.39 mM; Need ultrasonic)
Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named “Cuproptosis”. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism. Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.
MCE supplies a unique collection of 150+ cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have an inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.
MCE Isotope-labeled Compounds
| Product Name | Cas No. | Structure | |
| Deutenzalutamide |
1443331-82-5
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| Phenacetin-d5 |
69323-74-6
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| Venlafaxine-d6 hydrochloride | 1062606-12-5 |  |
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MCE Ni-NTA 6FF Prepacked Column is ideal for high performance purification of polyhistidine-tagged proteins expressed in E.coli, yeast, insect and mammalian expression systems.
Latest Publications Citing Use of MCE Products
Nature. 2022 Sep;609(7928):829-834.
Cell. 2022 Sep 1;185(18):3356-3374.e22.
Cancer Cell. 2022 Sep 12;40(9):1044-1059.e8.
Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9.
Cell Signaling Pathways
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