09 Jun [MCE]: New Bioactive Molecules for June 2022
MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 30,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via info@bio-etc.com.
CAS No.: 2711006-67-4
ZXH-4-130 TFA
Research Area: CRBN Degrader/Hetero-PROTAC
• Highly potent and selective PROTAC degrader of CRBN.
• Induces ~80% CRBN degradation at 10 nM in MM1.S cells.
Solubility: DMSO : 170 mg/mL (172.57 mM; Need ultrasonic)
CAS No.: 913541-47-6
SLX-4090
Research Area: DHODH Inhibitor/Malaria
• An orally active, enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor (IC50 of 8 nM).
• Reduces postprandial lipids in rats.
CAS No.: 1039342-24-9
MMI-0100
Research Area: MK2 Inhibitor/Vein Graft Disease
• A peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MAPKAPK2, MK2).
• Reduces intimal hyperplasia ex vivo and in vivo.
• Prevents vein graft intimal thickening ex vivo and in vivo.
CAS No.: 1380716-06-2
ML198
Research Area: Glucocerebrosidase Modulator/Gaucher Disease
• A glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM.
• An activator and non-inhibitory chaperone of glucocerebrosidase.
• Increases translocation of GCase to the lysosome in human fibroblasts.
Solubility: DMSO : 5 mg/mL (17.22 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)
CAS No.: 20287-37-0
Fenquizone
Research Area: Diuretic/Hypertension
• Orally active thiazide-like diuretic, exhibits chronic antihypertensive effect.
• Potent saluretic, has the potential for oedema and hypertension research.
| Compound Library | Description |
| MCE Anti-Colorectal Cancer Compound Library |
1,200+ compounds with identified and potential anti-colorectal cancer activity;
Targeting Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF and other target genes and signaling pathways. A useful tool for anti-colorectal cancer drugs screening and other related research. |
| MCE Children’s Drug Library | 600+ medicines have been approved or studied in clinical trials for children diseases; A useful tool for drug repurposing to discover new children’s indications, which greatly overcomes many objective problems such as lack of commercial interests, difficulties in trials and ethical concerns. |
Apoptosis, known as programmed cell death, is a carefully controlled, energy-dependent process of cell death. Induction of apoptosis results in a cascade of characteristic biochemical events resulting in changes in cellular morphology and death.
The detection of apoptosis includes methods related to cellular markers such as chromatin condensation, DNA fragmentation, mitochondrial damage, cell surface markers such as phosphatidylserine exposure and cell permeability. MCE provides a series of high-quality cell apoptosis assay kits to drive your research forward.
| Cat. No. | Product Name | Description | |||
| HY-K1070 |
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Chromatin Condensation | |||
| HY-K1071 |
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Chromatin Condensation | |||
| HY-K1072 |
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Chromatin Condensation | |||
| HY-K0601 |
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Mitochondrial Membrane Potential | |||
| HY-K1073 |
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Phosphatidylserine Exposure |
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| HY-K1074 |
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Phosphatidylserine Exposure |
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| HY-K1075 |
|
Phosphatidylserine Exposure |
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| HY-K1076 |
|
Phosphatidylserine Exposure |
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| HY-K1077 |
|
Phosphatidylserine Exposure |
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| HY-K1078 |
|
DNA Fragmentation (TUNEL Method) |
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| HY-K1079 |
|
DNA Fragmentation (TUNEL Method) |
Latest Publications Citing Use of MCE Products
Nature. 2022 May;605(7909):325-331.
Nature. 2022 Apr;604(7906):541-545.
Cell. 2022 Apr 28;185(9):1521-1538.e18.
Cancer Discov. 2022 May 2;candisc.0646.2021.
Cell Signaling Pathways
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