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| MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. |
| • Over 100,000 bioactive molecules in stock |
| • Target 10,000+ key proteins in 20+ signaling pathways |
| • Quality reports (LC/MS, NMR and HPLC) for each product |
| • Release more than 1,000 latest biochemicals per month |
| • Data sheet with detailed biological information |
| • High purity & competitive prices |
| • Delivery within 24 hours |
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CAS No.: 2851885-95-3
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Research Area: PROTAC/BCL6/Non-Hodgkin’s Lymphoma
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An orally active PROTAC that recruits BCL6 and the E3 ligase cereblon to rapidly degrade BCL6. |
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Shows DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines. |
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Used for the research of many types of non-Hodgkin’s lymphoma. |
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Solubility: DMSO: 20.83 mg/mL (23.19 mM; ultrasonic and warming and heat to 60°C)
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CAS No.: 313368-91-1
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Research Area: 5-HT Receptor/Dopamine Receptor/Neurological Diseases
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A 5-HT2A receptor antagonist (Ki of 0.54 nM), and a dopamine receptor modulator. |
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An orally atcive antipsychotic that can alleviate both schizophrenia and bipolar depression. |
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Solubility: DMSO: 125 mg/mL (317.66 mM; Need ultrasonic)
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CAS No.: 870762-83-7
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Research Area: LPL Receptor/S1P2/Cancer
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A selective sphingosine-1-phosphate receptor 2 (S1P2) agonist with an EC50 of 119 nM. |
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Protects neural-derived cell lines against Cisplatin toxicity. |
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Solubility: DMSO: 100 mg/mL (257.48 mM; Need ultrasonic)
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| MCE Apoptosis Analysis Kits |
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| Apoptosis assays encompass chromatin condensation, in situ DNA fragment detection, assessment of mitochondrial membrane potential, as well as identification of cell surface markers like phosphatidylserine (PS). MCE offers a range of high-quality apoptosis assay kits to support your scientific research endeavors |
| Cat. No |
Product Name |
Application |
HY-K1072
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Cell Apoptosis Analysis Kit (Hoechst staining) |
Chromatin Condensation |
HY-K1092
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YO-PRO-1/PI Apoptosis and Necrosis Detection Kit |
HY-K0601
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JC-1 Mitochondrial Membrane Potential Assay Kit |
Mitochondrial Membrane Potential |
HY-K1073
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Annexin V-FITC/PI Apoptosis Detection Kit |
Phosphatidylserine Exposure |
HY-K1080
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Annexin V-iFluor 488/PI Apoptosis Detection Kit |
HY-K1093
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VF 647A-Annexin V/PI Apoptosis Detection Kit |
HY-K1078
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One Step TUNEL Apoptosis Detection Kit (FITC) |
DNA Fragmentation (TUNEL Method) |
HY-K1079
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One Step TUNEL Apoptosis Detection Kit (Cyanine 3) |
HY-K1091
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TUNEL Apoptosis Detection Kit (Biotin) |
HY-K1088
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VF 488 Caspase 3 Assay Kit for Live Cells |
Caspase Detection |
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| MCE Natural Products |
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Over 40 cyclic peptide drugs are currently in clinical use, and the vast majority of clinically approved cyclic peptides are derived from
natural products, such as antimicrobials or human peptide hormones. |
| Product Name |
Description |
Heterophyllin B
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An active cyclic peptide that can be used for the study of esophageal cancer. |
Segetalin B
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A cyclopentapeptide with an estrogen-like activity. |
Jasplakinolide
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A potent actin polymerization inducer with fungicidal and anti-cancer activities. |
Pristinamycin IA
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A cycle-peptidic macrolactone antibiotic, and a substrate of P-glycoprotein and inhibits its function. |
Destruxin B
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A cyclic peptide with insecticidal and anticancer activities that induces apoptosis in tumor cells. |
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| MCE Compound Library |
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| Provides a professional compound library to serve research in multiple fields including cancer, immunity, and metabolism. |
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Latest Publications Citing Use of MCE Products |
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Nat Med.
2024 Jun;30(6):1696-1710.
Nature.
2024 Jun;630(8015):237-246.
Cell.
2024 Jun 6;187(12):2935-2951.e19. |
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