13 Feb [MCE]: New Bioactive Molecules for February 2023
MCE (MedChemExpress) provides a wide range of life science biochemicals, including more than 40,000 bioactive compounds, dye reagents, peptides, and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via info@bio-etc.com.
Dalazatide TFA
Research Area: Kv1.3 Inhibitor/Inflammatory Diseases
• A specific Kv1.3 potassium channel peptide inhibitor.
• Used in the study of autoimmune diseases such as multiple sclerosis.
• Inhibits delayed-type hypersensitivity, and suppresses the motility and activation of Tem cells in vivo.
CAS No.: 2171511-58-1
Amivantamab
Research Area: EGFR-MET Antibody/Immune Anticancer
• Inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes.
• Induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells.
• Exhibits anti-cancer activity in EGFR exon 20 insertion-driven NSCLC models.
CAS No.: 66529-17-7
Midaglizole
Research Area: α2-Adrenoceptor Antagonist/Blood Pressure/Blood Glucose
• A potent α2-adrenoceptor antagonist.
• Stimulates insulin release in vitro.
• Increases blood pressure and reduces blood glucose levels in vivo.
Solubility: DMSO : 162.5 mg/mL (ultrasonic)
CAS No.: 2523016-96-6
SK-575
Research Area: PROTAC PARP1 Degrader/Cancer
• A highly potent and specific PROTAC degrader of PARP1.
• Exhibits significant antitumor activity in breast cancer models.
Solubility: DMSO : 200 mg/mL (228.06 mM; Need ultrasonic)
CAS No.: 2360853-16-1
RBN-3143
Research Area: PARP14 Inhibitor/Inflammatory Diseases
• A selective PARP14 inhibitor with an IC50 value of 4 nM.
• Inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cells.
• Used in research on inflammation. Improves steroid-resistant asthma in vivo.
Solubility: DMSO : 12.5 mg/mL (27.81 mM; ultrasonic and warming and heat to 80°C)
Heterocycles are common in biology, featuring a wide range of structures from enzyme co-factors to amino acids and proteins. On the one hand, heterocycles are common structural units in approved drugs and in medicinal chemistry targets in the drug discovery process. In addition, heterocycles have been found as a key structure in medical chemistry and also they are frequently found in a large percent of biomolecules such as vitamins, natural products, and biologically active compounds including antifungal, anti-inflammatory, antibacterial, antioxidant, antiallergic, anti-HIV, antidiabetic, anticancer activity.
MCE offers a unique collection of 5,500+ heterocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE heterocyclic compound library is critical for drug discovery and development.
MCE Isotope-labeled Compounds
| Product Name | Cas No. | Structure |
| L-Aspartic acid-1,4-13C2 |
101247-29-4
|
 |
| L-Aspartic acid-15N |
3715-16-0
|
 |
| L-Homocysteine-d4 |
416845-90-4
|
 |
| L-Leucine-1-13C,15N |
80134-83-4
|
 |
| L-Valine-1-13C |
81201-85-6
|
 |
MCE Glycan
Glycan is a complex polymer composed of many monosaccharide molecules with covalent bonds. They are large in number and wide in variety and decorate the cell surface. Glycan is an important marker of cell “identity”, which helps cells communicate with each other or with the external environment. Some studies have shown that glycans play a key role in many major diseases such as cancer and autoimmune diseases.
| Product Name | Cas No. | Description |
| Maltopentaose |
34620-76-3
|
The shortest chain oligosaccharide can be classified as maltodextrin and is also used in a study to investigate glycation and phosphorylation of α-lactalbumin. |
| Heparan Sulfate |
9050-30-0
|
Existing as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix. |
| Stachyose tetrahydrate |
10094-58-3
|
Preventing indirectly colon cancer cell growth by promoting the proliferation of probiotics or producing beneficial materials in the intestine. |
| Laminaran |
9008-22-4
|
A typical ligand for Dectin-1, has potent immunomodulating, radioprotective, and anticancer activities. |
Latest Publications Citing Use of MCE Products
Nature.
2023 Jan;613(7942):187-194.
Nature.
2022 Dec;612(7941):725-731.
Nature.
2023 Jan;613(7942):145-152.
Nature.
2023 Jan;613(7942):120-129.
Immunity.
2023 Jan 10;56(1):180-192.e11.
Cell Signaling Pathways
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