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[MCE]: New Bioactive Molecules for August 2022

18 Aug [MCE]: New Bioactive Molecules for August 2022

Posted at 02:33h in News by
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MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 40,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via info@bio-etc.com.

 

CAS No.: 1443994-46-4
Mongersen
Research Area: Smad7 ASO/Crohn’s Disease

• An orally active SMAD7 antisense oligonucleotide.
• Inhibits TGF-β1 pathways and alleviates Crohn’s disease.

 

 

 

 

 

CAS No.: 1709886-74-7
Tominersen
Research Area: Huntingtin Protein ASO/Huntington’s Disease

• A second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production.
• Used for the research of Huntington’s disease.

 

 

 

CAS No.: 2743427-26-9
GSK215
Research Area: FAK Degrader

• A selective PROTAC degrader of focal adhesion kinase (FAK).
• Induces rapid and prolonged FAK degradation.
• Long-lasting effect on FAK levels and a marked PK/PD disconnect.

Solubility: DMSO : 250 mg/mL (253.77 mM; Need ultrasonic)

 

 

 

CAS No.: 71145-03-4
Bay K 8644
Research Area: Calcium Channel Activator

• A specific L-type Ca2+ channel agonist.
• Increases Ca2+ influx through sarcolemmal Ca2+ channels by increasing the open time of the channel.
• Possesses positive inotropic, vasoconstrictive and behavioral effects.

Solubility: DMSO : 83.33 mg/mL (233.88 mM; Need ultrasonic)

 

 

 

Dalpiciclib hydrochloride
Research Area: CDK/Breast Cancer/Eesophageal Squamous Cell Carcinoma

• An orally active and highly selective inhibitor of CDK4/6.
• Shows antitumor activity against breast cancer and esophageal squamous cell carcinoma.
• Exerts antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest.

Solubility: DMSO : 5 mg/mL (10.35 mM; ultrasonic and warming and heat to 60°C)

 

 

MCE EMA-Approved Drug Library/ FDA-Approved Anticancer Drug Library
Compound Library Description
EMA-Approved Drug Library
600+ EMA-approved drugs with high pharmacological diversity;
MCE EMA-Approved Drug Library is a useful tool for drug repurposing which could dramatically accelerate drug development.
FDA-Approved Anticancer Drug Library 1000+ approved drugs with anti-cancer activity;
MCE FDA-Approved Anticancer Drug Library can be used for discovery of new anti-cancer drugs or as positive compounds used for anti-cancer research, which will dramatically accelerate drug development.

Natural products of microorganisms

In 1928, Alexandra Fleming discovered penicillin and created a new field of microbial drugs. In the following decades, the drug development of microbial natural products has always been a hot spot and frontier in the field of new drug research and development. The secondary metabolites produced by microorganisms have a variety of biological activities, which can be used as anticancer drugs, antiparasitic drugs, anti-inflammatory drugs, immunosuppressants and so on, and play an important role in human health.
Product Name Description
Fusicoccin Stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth.
Gliotoxin Inhibiting the phagocytosis of macrophages and the immune functions of other immune cells.
Aflatoxin M1 A major metabolite of Aflatoxin B1.
Manumycin A Acting as a selective, competitive inhibitor of protein farnesyltransferase (FTase).
Cercosporin A potent photosensitizer, PKC inhibitor.

 

Latest Publications Citing Use of MCE Products

Nature. 2022 Jul;607(7917):135-141.
Nature. 2022 May;605(7910):567-574.
Cell. 2022 Jun 23;185(13):2234-2247.e17.
Immunity. 2022 Jul 7;S1074-7613(22)00280-1.

 

 

Cell Signaling Pathways