Bio.etc Pte Ltd | [MCE] New Bioactive Molecules for April 2026

24 Apr [MCE] New Bioactive Molecules for April 2026

Posted at 03:56h in News by Editorial Bio.etc

0 Likes

MedChemExpress - Master of Bioactive Molecules (Inhibitors. Screening Libraries. Proteins)

MedChemExpress (MCE) provides an extensive collection of life-science biochemicals, including over 150,000+ bioactive compounds, dye reagents, peptides and natural compounds for research applications.

CAS No.: 2117405-48-6

SW203668 TFA

Research Area: Stearoyl-CoA desaturase (SCD)/Non-small Cell
Lung Cancer (NSCLC)

•	An irreversible stearoyl-CoA desaturase (SCD) inhibitor with an IC₅₀ of 54 nM.
•	Exhibits selective cytotoxicity against cell lines expressing CYP4F11.
•	Can be used in the research on NSCLC.

Solubility: DMSO: 100 mg/mL (198.61 mM; Need ultrasonic)

CAS No.: 2595179-74-9

DIM-3,5-Cl2

Research Area: Nuclear Hormone Receptor
4A/NR4A/Ferroptosis/Cancer/Endometriosis

•	An inverse NR4A1/NR4A2 agonist, binds both NR4A1 and NR4A2, reduces transcriptional activity.
•	Induces ferroptosis in triple-negative breast cancer (TNBC) cells.
•	Can be used in the research on colorectal cancer, TNBC and endometriosis.

Solubility: DMSO: 100 mg/mL (255.56 mM; Need ultrasonic)

CAS No.: 3070379-34-6

ZLY025

Research Area: Molecular Glues/CDK/Apoptosis/Non-small Cell
Lung Cancer (NSCLC)

•	An orally active and selective CCNK molecular glue degrader with an DC₅₀ of 42.7 nM.
•	Induces apoptosis and G1 phase arrest in cancer cells.
•	Can be used in the research on NSCLC.

Solubility: DMSO: 5 mg/mL (16.70 mM; Need ultrasonic)

MedChemExpress FluoroStock & Ready

Newly launched, offering high-concentration stock solutions of commonly used
fluorescent dyes with simplified operation, low reagent loss, and excellent
reproducibility, thereby significantly enhancing experimental stability and
efficiency.

Application	Product Name
Celluar Organelle Dyes	SYTO9 (solution)
	DAPI dihydrochloride (solution)
	DiD perchlorate (solution)
	Oil Red O (solution)
	7-Aminoactinomycin D (solution)
Cell Behavior Analysis Probes	Thiazolyl Blue (solution)
	Calcein (solution)
	BODIPY FL-C16 (solution)
	FITC-Dextran (MW 70000) (solution)
Ion Fluorescent Indicators	Coppersensor 1 (solution)
	Zinquin (solution)
	Fura-2 AM (solution)
	Fluo-3AM (solution)

MedChemExpress Kits

MCE staining kits are developed based on classical histological staining
principles and feature optimized formulations. By employing selective dyes or
specific chemical reaction systems, these kits enable clear color contrasts
among different biological components such as cell nuclei, cytoplasm, lipids,
collagen fibers, and elastic fibers, thereby allowing clear visualization of
tissue architecture and cellular morphology. These kits offer simple operation,
high reproducibility, and stable staining performance, and are widely used in
histomorphological observation, pathological research, as well as cell biology
analysis.

Product Name	Application
Alcian Blue Staining Solution (pH 2.5)	Detection of acidic mucopolysaccharides and mucins.
Methenamine Silver Stain Kit For Basement Membrane (PASM)	Evaluation of morphological changes in the glomerular basement membrane.
Sirius Red Staining Kit	Assessment of collagen deposition and fibrosis.
Human iPSC/ESC Cortical Brain Organoid Maturation Medium	Muscle fiber typing and staining.

MedChemExpress Cellular Digestive Enzymes

Enzymes used to dissociate adhered or aggregated cells from the culture
substrate.

Product Name	Source	Application
Trypsin	Vertebrate	Common cell lines
Recombinant Trypsin Solution	Recombinant expression	Weak adherent cells or stem cells
Neutral protease	Bacillus polymyxa	Primary cell
DNase I	Bovine pancreas	Degrade circulating free DNA. In single-cell sequencing, collagenase can be used in combination to prepare single-cell suspensions.
Recombinant DNase I (RNase-free)	Recombinant expression

MedChemExpress Natural Products

Aging is an inevitable process caused by physicochemical changes that lead to
cellular senescence. Anti-aging research aims to extend lifespan and improve
quality of life by addressing age-related diseases such as Parkinson’s,
Alzheimer’s, cardiovascular disease, cancer, and COPD. Natural products have been shown to delay aging by modulating metabolic pathways.

Product Name	Highlights
Rapamycin	A blood-brain barrier-transmissible mTOR inhibitor.
Cordycepin	Restores circadian rhythms in the hypothalamic paraventricular nucleus, reverses aging biomarkers and extends lifespan in male mice.
Ganoderic acid A	Extends the lifespan of nematodes and maintains ribosome homeostasis.
Procyanidin C1	Inhibits SASP formation, eliminates senescent cells, and prolongs mouse lifespan.
Spermidine	Induces mitochondrial autophagy and has anti-aging property.

MedChemExpress Compound Library

MCE offers professional compound library, serving cancer, immunity, metabolism and other fields of research.

Product Name	Description
Pattern Recognition Receptors Library	This library includes 270+ pattern recognition receptor-targeted compounds, which can be used in drug research related to chronic inflammatory diseases.

MedChemExpress Isotope-labeled Compounds

Latest Publications Citing Use of MCE Products
	Nature. 2026 Mar;651(8105):451-461. Nature. 2026 Feb;650(8103):961-969. Nature. 2026 Feb;650(8103):951-960. Cell. 2026 Mar 5;189(5):1481-1498.e22. Cell. 2026 Mar 5;189(5):1451-1464.e27.