[MCE] Epigenetics Compound Library

28 Jul [MCE] Epigenetics Compound Library

Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases.

MCE provide a unique collection of 1072 epigenetics-related compounds that can be used in the research of the related diseases.

MCE Epigenetics Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 1058 compounds supplied in 10 mM solution, 11 compounds supplied in 2 mM solution and 3 compounds supplied in 3 mg/mL solution.

[For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.]

Key Highlights

• A unique collection of 1072 small molecule modulators with biological activity used for epigenetics research and associated assays
• The library contains epigenetics-related compounds targeting HDAC, Histone Demethylase, Histone Acetyltransferase (HAT), DNA Methyltransferase (DNMT), Epigenetic Reader Domain, MicroRNA, etc
• A valuable tool for chemical genomics, epigenetic target identification in pharmacogenomics, and other biological applications
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA
• Structurally diverse, medicinally active, and cell permeable
• Rich documentation with structure, IC50, and other chemical & biological data.
• NMR and HPLC validated to ensure the highest purity
• All compounds are in stock and continuously updated