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Oligonucleotides are specially designed sequences of nucleotides, which can be used as antisense oligonucleotides (ASOs), small interfering RNA (siRNA), microRNA (miRNA), aptamers, etc. Oligonucleotides can hybridize with target gene mRNA or pre-mRNA through complementary base pairing and modulate gene expression via various processes, including RNA interference...

MedChemExpress (MCE) provides a wide range of life-science biochemicals, including more than 100,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via CAS No.: 1421854-16-1 AC-186 Research Area: Estrogen Receptor/ERR/Neurological Disease • A...

MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. •  Over 50,000 bioactive molecules in stock •  Target 1,000+ key proteins in 20+ signaling pathways •  Quality reports (LC/MS, NMR...

Cellular Senescence in Cornelia de Lange Syndrome : A Pharmacological Target? Tuesday, April 30, 2024 CEST 10:00 / IST 13:30 / JST & KST 17:00 Dr. Michel Pucéat • Research director at Inserm • Team leader and senior researcher In This Webinar, You Will Learn: • Programmed embryonic cell senescence in cardiac...

Tumor Immunotherapy During tumor development, immunotherapy inhibits highly expressed immune checkpoint molecules to restore T-cell recognition, thereby clearing or slowing tumor progression[1]. Immune Checkpoint Inhibitory Antibody Programmed cell death 1 (PD-1) is the T-cell immune checkpoint molecule of greatest interest. PD-1 or PD-L1 inhibitory antibodies upregulate T-cell activation and activate...