06 Aug [ADIPOGEN]: IMMUNE RESPONSE BIOMARKER DETECTION WITH SENSITIVE ELISA ASSAYS
UNIQUE & SPECIFIC ELISA ASSAYS IMMUNO-ONCOLOGY – INFLAMMATION – OBESITY
NEWIMMUNO-ONCOLOGY BIOMARKER ASSAYS
B7-H3 (CD276) (HUMAN) ELISA KIT
The B7-H3 (CD276) (human) ELISA Kit (Prod. No. AG-45B-0025) is a sandwich ELISA for specific quantitative determination of soluble human B7-H3 (CD276) in serum, plasma and cell culture supernatants.
Sensitivity: 0.3 ng/ml – Range: 0.3125 – 20 ng/ml
Review: B7-H3 Immune Checkpoint Protein in Human Cancer: K. Flem-Karlsen, et al.; Curr. Med. Chem. 27, 4062 (2020) | The Role of CD276 in Cancers: S. Liu, et al.; Front. Oncol. 11, 654684 (2021)
PD-1 (CD279) (HUMAN) ELISA KIT
The PD-1 (CD279) (human) ELISA Kit (Prod. No. AG-45B-0015) is a sandwich ELISA for specific quantitative determination of human soluble PD-1 in serum, plasma and cell culture supernatants.
Sensitivity: 1.6 pg/ml – Range: 3.125 – 200 pg/ml
Review: Soluble PD-1: Predictive, Prognostic, and Therapeutic Value for Cancer Immunotherapy: M. Khan, et al.; Front. Immunol. 11, 587460 (2020)
PD-L1 (CD274) (HUMAN) ELISA KIT
The PD-L1 (CD274) (human) ELISA Kit (Prod. No. AG-45B-0016) is a sandwich ELISA for specific quantitative determination of human soluble PD-L1 in serum, plasma and cell culture supernatants.
Sensitivity: 0.8 pg/ml – Range: 2.34 – 150 pg/ml
Review: Non-cytomembrane PD-L1: an atypical target for cancer: H. Ying, et al.; Pharmacol. Res. 105741 (2021) (Review)
ICOSL (B7-H2/CD275) (HUMAN) ELISA KIT
The ICOSL (B7-H2/CD275) (human) ELISA Kit (Prod. No. AG-45B-0017) is a sandwich ELISA for specific quantitative determination of soluble human ICOSL [B7-H2/CD275] in serum, plasma and cell culture supernatants.
Sensitivity: 55 pg/ml – Range: 0.0625 – 4 ng/ml
Review: The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy: C. Solinas, et al.; ESMO Open 5, e000544 (2020)
CD40L (HUMAN) ELISA KIT
The CD40L (human) ELISA Kit (Prod. No. AG-45B-0018) is a sandwich ELISA for specific quantitative determination of human soluble CD40L in serum, plasma and cell culture supernatants.
Sensitivity: 20 pg/ml – Range: 0.03125 – 2 ng/ml
Review: CD40/CD40L Signaling as a Promising Therapeutic Target for the Treatment of Renal Disease: S. Zhang, et al.; J. Clin. Med. 9, 3653 (2020)
NEW INHIBITORY LIGAND OF IMMUNE RECEPTOR LAG-3
FGL1 (HUMAN) ELISA KIT
The FGL1 (human) ELISA Kit (Prod. No. AG-45B-0022) is a sandwich ELISA for specific quantitative determination of human FGL1 in serum, plasma and cell culture supernatants. FGL1 is upregulated by human cancer cells, and increased levels of FGL1 in the serum/plasma of cancer patients is associated with a poor prognosis of anti-PD-1 therapy.
Sensitivity: 1.8 pg/ml – Range: 7.8 to 500 pg/ml
LIT: Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3: J. Wang, et al.; Cell 176, 334 (2019)
NEW Marker for Inflammatory Diseases
GASDERMIN E (HUMAN) ELISA KIT
The Gasdermin E (human) ELISA Kit (AG-45B-0024) detects the C-terminal domain of human Gasdermin E as well as the full-length protein in serum, plasma and cell culture supernatant. Upon cleavage of Gasdermin E and pore formation, the C-terminus fragment should be released in the extracellular space and found in serum/plasma. The role of the C-terminus fragment of the Gasdermin protein family is unclear but potentially associated to Gasdermin E-mediated pyroptosis and inflammatory diseases.
Sensitivity: 50 pg/ml – Range: 0.0625 to 4 ng/ml
NEW & Sensitive Biomarker for Obesity Research
ACYL-COA-BINDING PROTEIN (ACBP) (HUMAN) ELISA KIT
The ACBP (human) ELISA Kit (Prod. No. AG-45B-0019) is a sensitive and robust sandwich ELISA for specific quantitative determination of human ACBP in serum, plasma and cell culture supernatants. Obese patients exhibit elevated plasma levels of ACBP, while a reduction in ACBP plasma concentration is observed in these patients after a substantial weight loss. ACBP might act as a “Hunger Factor” useful for the prevention or treatment of obesity and metabolic syndrome diseases.
Sensitivity: 30 pg/ml – Range: 0.03125 to 2 ng/ml
LIT: Acyl-CoA-binding protein (ACBP): a phylogenetically conserved appetite stimulator: N. Charmpilas, et al.; Cell Death Dis. 11, 7 (2020)
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