08 Nov [Adipogen]: eTOPIX_APRIL and BAFF in Immune Response and Athersosclerosis
• BAFF and APRIL are cytokines implicated in B cells survival & activation and in several human autoimmune diseases.
• A recent study reports that APRIL confers atheroprotection by binding to heparan sulfate chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits the retention of low-density lipoproteins and accumulation of macrophages.
• AdipoGen’s specific anti-APRIL (mouse) antibody (Apry-1-1) promotes the binding of APRIL to HSPGs to reduce experimental atherosclerosis.
UNIQUE APRIL Antibody Reduces Atherosclerosis
APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1)
AdipoGen Life Sciences’ anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1) (Prod. No. AG-27B-0001) is a recombinant monoclonal antibody that recognizes mouse APRIL and works specifically in IP and Functional Application. The antibody inhibits mouse APRIL binding to BCMA and TACI. It is highly potent in blocking mouse APRIL in vitro and in vivo. In addition it promotes the binding of APRIL to HSPGs and confers atheroprotection.
LIT: APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans: D. Tsiantoulas, et al.; Nature 597, 92 (2021)
NEW APRIL-Depleting Monoclonal Antibody
APRIL (mouse), mAb (blocking) (Centotto-1)
AdipoGen Life Sciences’ anti-APRIL (mouse), mAb (blocking) (Centotto-1) (preservative free) (Prod. No. AG-20B-0083PF) is a monoclonal antibody that recognizes mouse APRIL and works specifically in IP and Functional Application. This antibody depletes mouse APRIL in vivo.
LIT: APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans: D. Tsiantoulas, et al.; Nature 597, 92 (2021)
Comprehensive Panel of APRIL/BAFF Reagents
The APRIL (human) ELISA Kit (Prod. No. AG-45B-0012) is a sandwich ELISA for specific quantitative determination of human APRIL in serum, plasma and cell culture supernatants. This ELISA Kit shows both high specificity and high sensitivity, which is a clear advantage compared to other APRIL (human) ELISA Kits from key competitors.
Sensitivity: 1 pg/ml – Range: 3.9 – 250 pg/ml
The Most RELIABLE Assay
BAFF, Soluble (human) ELISA Kit (hypersensitive)
The BAFF, Soluble (human) ELISA Kit (Prod. No. AG-45B-0001) is a sandwich ELISA for specific quantitative determination of human BAFF in serum, plasma and cell culture supernatants. This ELISA Kit does not cross-react with mouse BAFF and has been chosen by several CROs for its high specificity and high sensitivity.
Sensitivity: 8 pg/ml – Range: 15.6 – 500 pg/ml
UNIQUE & POTENT
BAFF (mouse), mAb (blocking) (Sandy-2)
AdipoGen Life Sciences‘ anti-BAFF (mouse), mAb (blocking) (Sandy-2) (Prod. No. AG-20B-0063) is a monoclonal antibody that recognizes mouse BAFF and works specifically in IP and Functional Application. The antibody inhibits mouse BAFF binding to BAFF-R and TACI. It is highly potent in blocking mouse BAFF in vivo and induces B cell depletion and generates a phenotype similar to that observed in BAFF-/- mice.
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