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August 2025

15 Aug

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MedChemExpress (MCE) provides an extensive collection of life-science biochemicals, including over 100,000 bioactive compounds, dye reagents, peptides and natural compounds for research applications. CAS No.: 2980682-00-4 RP-1664 Research Area: Polo-like Kinase (PLK)/Breast Cancer/Neuroblastoma • A selective and orally active PLK4 inhibitor with an IC50 of 3 nM. • Disrupts centriole biogenesis in...

15 Aug

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The Critical Role of Protein-Protein Interactions (PPIs) PPIs serve as fundamental regulatory events of many cellular processes, including signal transduction, proliferation, and apoptosis. With an estimated 650,000 PPIs in humans[1], these interactions form intricate networks that govern protein function. Dysregulated PPIs are implicated in diseases such as...

15 Aug

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Type 2 Diabetes Mellitus (T2D) accounts for approximately 96% of all diabetes cases, making it one of the most prevalent noncommunicable chronic diseases and a major global public health concern[1]. T2D is characterized by a non-autoimmune, progressively heterogeneous decline in functional insulin secretion from pancreatic β-cells....